(2-Hydroxypropyl)-γ-cyclodextrin (HP-γ-CD),CAS 128446-34-4, is a chemically modified derivative of γ-cyclodextrin, a cyclic oligosaccharide composed of eight glucose units linked by α-1,4-glycosidic bonds. The modification involves the substitution of hydroxypropyl groups onto the hydroxyl groups of the glucose units, enhancing the solubility and functional properties of the parent cyclodextrin. This article delves into the characteristics, pharmaceutical applications, and advantages of HP-γ-CD, with a particular focus on its role as a pharmaceutical excipient.