Introduction of β-nicotinamide mononucleotide
Nicotinamide mononucleotide is also called β-nicotinamide mononucleotide (β-NMN), which is a synthetic substrate for Coenzyme I, and NMN is also used in anti-aging research. Research shows that β-NMN can also regulate the secretion of insulin and affect the expression level of mRNA. β-NMN has a wide application prospect in the field of medical treatment.β-nicotinamide mononucleotide is a product of extracellular nicotinamide phosphoribosyl transferase reactions and a key NAD+ intermediate.β-nicotinamide mononucleotide improves glucose tolerance by restoring NAD+ levels in HFD-induced T2D mice.β-NMN also enhances liver insulin sensitivity and restores gene expression associated with oxidative stress, inflammatory response, and circadian rhythms, in part through SIRT1 activation.