Introduction of β-nicotinamide mononucleotide
Nicotinamide mononucleotide is also called β-nicotinamide mononucleotide (β-NMN), which is a synthetic substrate for Coenzyme I, and NMN is also used in anti-aging research. Research shows that β-NMN can also regulate the secretion of insulin and affect the expression level of mRNA. β-NMN has a wide application prospect in the field of medical treatment.β-nicotinamide mononucleotide is a product of extracellular nicotinamide phosphoribosyl transferase reactions and a key NAD+ intermediate.β-nicotinamide mononucleotide improves glucose tolerance by restoring NAD+ levels in HFD-induced T2D mice.β-NMN also enhances liver insulin sensitivity and restores gene expression associated with oxidative stress, inflammatory response, and circadian rhythms, in part through SIRT1 activation.
What is the appearance of β-nicotinamide mononucleotide?
The appearance of β-nicotinamide mononucleotide is white to yellowish crystalline powder which has no obvious odor.
Where is the source of β-nicotinamide mononucleotide?
β-nicotinamide mononucleotide(β-NMN) is an intrinsic substance in the human body，β-NMN is also found in some fruits and vegetables, including broccoli and cabbage.
What is the using of β-nicotinamide mononucleotide?
In mammals, β-nicotinamide mononucleotides are produced from nicotinamide catalyzed by Nampt.Subsequently, niacinamide mononucleotide is catalyzed by nicotinamide mononucleotide adenosyltransferase to produce NAD+. Nicotinamide mononucleotide is a direct way to supplement NAD+. Niacinamide mononucleotides can reverse aging by significantly improving the repair ability of DNA damage in cells. Nicotinamide mononucleotides are converted into "nicotinamide adenine dinucleotide (NAD)" which is essential for energy metabolism in the body. NAD is a substance that the body can originally produce, and studies have shown that the amount of NAD in the body decreases with age. β-nicotinamide mononucleotide is also very hot in food supplement market in recent years.
What is the application of β-nicotinamide mononucleotide?
β-nicotinamide mononucleotide is the precursor of NAD+, the cofactor of longevity protein in human body. NAD+ is an important coenzyme in the tricarboxylic acid cycle, which promotes the metabolism of sugars, fats and amino acids and participates in the synthesis of energy. NAD+ is the only substrate of coenzyme I consuming enzyme. NAD+ is a key coenzyme involved in all aspects of human metabolism, Lack of NAD+, metabolism is not good, the elderly lack of NAD+, so a variety of big and small problems will come, through the additional supplement of NAD+, you can fully anti-aging.
Where to buy β-nicotinamide mononucleotide ?
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Certificate of Analysis of β-nicotinamide mononucleotide
Items | Specifications | Results |
Appearance | White to yellowish powder | Conforms |
Purity（HPLC） | ≥98% | 99.8% |
Sodium content(IC) | ≤1% | N.D |
Water content(KF) | ≤5% | 0.060% |
pH value in water(100mg/ml) | 2.0-4.0 | 3.14 |
Heavy metal content(AAS) | Pb≤0.5ppm | Conforms |
As≤0.5ppm | Conforms | |
Hg≤0.5ppm | Conforms | |
Cd≤0.5ppm | Conforms | |
Total microbial count(GB 4789.2) | ≤750 CFU/g | 100CFU/g |
Coliform(GB4789.3) | ＜3MPN/g | N.D |
Ethanol(By GC) | ≤2% | 0.022% |
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