Ketoibuprofen is a white crystalline powder, odorless or almost odorless; Very soluble in methanol, soluble in ethanol, acetone or ether, almost insoluble in water.
Ketobuprofen is widely used to treat various types of rheumatoid arthritis, ankylosing spondylitis, osteoarthritis pain, as well as dysmenorrhea, toothache, postoperative pain, cancer pain, and acute renal colic, and other pains.
Ketoibuprofen, as an important non-steroidal anti-inflammatory drug, has significant advantages such as small dose, high efficacy, good tolerance and mild side effects compared with similar drugs.
Ketoprofen CAS 22071-15-4
Ketoprofen is a medication belonging to a class of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs). It works by reducing hormones in the body that cause inflammation, pain, and fever.
Primary Uses:
Ketoprofen is used to treat a variety of conditions involving pain and inflammation, including:
Pain Relief: Mild to moderate acute pain (e.g., post-surgical pain, dental pain).
Inflammatory Conditions:
Rheumatoid Arthritis: An autoimmune disorder causing joint inflammation.
Osteoarthritis: Degenerative joint disease (wear-and-tear arthritis).
Ankylosing Spondylitis: Inflammation of the spine and large joints.
Acute Gout: Sudden, severe attacks of joint pain and swelling caused by uric acid crystals.
Musculoskeletal Disorders: Such as sprains, strains, tendinitis (e.g., tennis elbow), and bursitis.
Menstrual Cramps (Dysmenorrhea): To relieve the pain and cramping associated with menstrual periods.
How It's Available:
Oral Forms: Immediate-release and extended-release capsules or tablets.
Topical Forms: Gels, creams, or patches (available in some countries) applied directly to the skin over the painful area for localized relief (e.g., for osteoarthritis in superficial joints like the knees).
Important Mechanism:
Like other NSAIDs, Ketoprofen works by inhibiting the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). These enzymes are involved in the production of prostaglandins, which are chemicals that promote inflammation, pain, and fever. By blocking them, Ketoprofen reduces these symptoms.
Key Warnings and Side Effects:
Gastrointestinal (GI) Risks: Can cause stomach irritation, ulcers, and bleeding, especially with long-term use or in older adults.
Cardiovascular Risks: Like most NSAIDs (except aspirin), it may increase the risk of heart attack, stroke, and blood clots, particularly with high doses or prolonged use.
Kidney Damage: Can impair kidney function, especially in those with existing kidney problems, heart failure, or who are dehydrated.
Other Common Side Effects: Heartburn, nausea, headache, dizziness, and rash.
Allergic Reactions: Can occur, especially in people allergic to aspirin or other NSAIDs (may cause asthma attacks in susceptible individuals).
Important Considerations:
Prescription-Only: In most countries, Ketoprofen is available only with a doctor's prescription.
Short-Term Use: Often recommended for the shortest duration possible at the lowest effective dose.
Not for Everyone: Contraindicated in people with a history of stomach ulcers, severe heart, kidney, or liver disease, and in the third trimester of pregnancy.
Drug Interactions: Can interact with blood thinners (e.g., warfarin), other NSAIDs, certain antidepressants (SSRIs/SNRIs), and diuretics.
Disclaimer: This information is for educational purposes only. Always consult a doctor or pharmacist before taking any medication to ensure it is safe and appropriate for your specific health situation. They will consider your medical history and other medications you are taking.
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