BMS-186295 CAS 138402-11-6 Wholesale & Bulk

 BMS-186295 CAS 138402-11-6 Wholesale & Bulk

BMS-186295 is an angiotensin II receptor inhibitor, angiotensin II receptors are divided into AT1, AT2. BMS-186295 by selectively blocking the AT1 receptor of AnglII, it can inhibit the conversion of AngI into AngII, and can specifically antagonize the ACE 1 receptor (AT1). BMS-186295's antagonistic effect on AT1 is 8500 times that of AT2, which inhibits vasoconstriction and the release of aldosterone by selectively blocking AngII's binding to AT1 receptors, resulting in a hypotensive effect.

 

BMS-186295 does not inhibit angiotensin-converting enzyme (ACE), renin, other hormone receptors, nor do they inhibit ion channels associated with blood pressure regulation and sodium balance. BMS-186295 can also reduce the electrical remodeling of the myocardium, thereby reducing the mortality rate of hypertensive patients, and is currently the most effective drug for the treatment of hypertension and cardiovascular diseases.

 

 

Specifications of BMS-186295 CAS 138402-11-6

 

Tests	Standard	Results
Appearance	White to almost white crystalline powder	Almost white crystalline powder
Solubility	Slighttly soluble in alcohol and in methylene Chloride ,practically insoluble in water	qualified
Water	≤0.5%	0.4%
Limit of azide	≤10ppm	＜1ppm
Heavy metals	≤0.002%	＜0.002%
Assay(HPLC)	98.0%~102.0%	99.5%

 

 

Parameters of BMS-186295 CAS 138402-11-6

Product parameters
Cas number:	138402-11-6
Appearance:	White to almost white crystalline powder
Purity:	98~102%
Package details:	25kg/drum
Brand:	Fortunachem

 

Package of our Irbesartan CAS 138402-11-6 Wholesale

 

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