Doxorubicin hydrochloride inhibits the topoisomerase II of DNA supercoiling by interlodicating and inhibiting polymer biosynthesis and DNA interaction. Doxorubicin prevents the closing of the DNA double helix, thereby disrupting the replication of DNA strands. By embedding, doxorubicin can also act on transcribally active chromatin, resulting in changes in histones.
Doxorubicin hydrochloride is a non-cyclical specific antitumor drug, the anti-tumor spectrum is wide, it can be used clinically for breast cancer, lung cancer, lymphoma, ovarian cancer and other cancers.
Specifications of Doxorubicin Hydrochloride CAS 25316-40-9
Item | Specifications | Results |
Appearance | Orange-red or red crystalline powder | Conform |
PH | 4.0 – 5.5 | 4.9 |
Acetone | ≤0.5% | 0.34% |
Water | ≤4.0% | 2.1% |
Assay | 98.0% - 102.0% | 99.2% |
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